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Table 4 Demographic, tumour and ductal lavage characteristics of women who developed breast cancer after study entry

From: Nipple aspiration and ductal lavage in women with a germline BRCA1 or BRCA2 mutation

  Subject
  PMC13 PMC11 PMC14 PMC15 RMH08
Age (years) 53 51 41 48 37
BRCA mutation A1 A1 A1 A1 A1
Menopause status Post Post Pre Post Pre
Prior contralateral breast cancer (age in years) No Yes (42) Yes (35) Yes (38) Yes (34)
Previous mammogram (months) 12 (normal) 7 (normal) 5 (normal) 5 (normal) 7 (normal)
Previous CBE (months) 6 1 5 5 7
'Regular' BSEa Yes Yes Yes Yes Yes
Mode of detection Mammography Self Self Self Self
Distance from nipple (cm) 5 3 Not recorded Not recorded 2
Histological characteristics Atypical medullary Lobular Ductal Ductal Ductal
   Size (mm) 5.2 20 10, 14, 10 (X3 separate foci) 1.8 5
   Grade 3 3 3 3 3
   ER status Negative Negative Negative Negative Negative
   PR status Negative Negative Negative Negative Negative
   Nodes Negative Negative Negative Negative Negative
Ductal lavage      
   Previous (months) 5 1 5 12 4
   No. ducts cannulated/breast 1 (X1occ) 2 (X1occ) 1 (X2occ) 1 (X1occ) Unsuccessful
   Cell count (duct)/ml 6,666 2,500, 6,666 47,700 + 4,000 15,000  
   Total cell count (duct) 79,992 35,000, 93,324 525,555 + 40,000 180,000  
   Cytology score Mild atypia Benign Benign No epithelial cells  
  1. a'Regular' as reported by subject (frequency not recorded). BSE, breast self examination; CBE, clinical breast examination; ER, oestrogen receptor; PR, progesterone receptor.