Table 4 Demographic, tumour and ductal lavage characteristics of women who developed breast cancer after study entry
From: Nipple aspiration and ductal lavage in women with a germline BRCA1 or BRCA2 mutation
Subject | |||||
|---|---|---|---|---|---|
PMC13 | PMC11 | PMC14 | PMC15 | RMH08 | |
Age (years) | 53 | 51 | 41 | 48 | 37 |
BRCA mutation | A1 | A1 | A1 | A1 | A1 |
Menopause status | Post | Post | Pre | Post | Pre |
Prior contralateral breast cancer (age in years) | No | Yes (42) | Yes (35) | Yes (38) | Yes (34) |
Previous mammogram (months) | 12 (normal) | 7 (normal) | 5 (normal) | 5 (normal) | 7 (normal) |
Previous CBE (months) | 6 | 1 | 5 | 5 | 7 |
'Regular' BSEa | Yes | Yes | Yes | Yes | Yes |
Mode of detection | Mammography | Self | Self | Self | Self |
Distance from nipple (cm) | 5 | 3 | Not recorded | Not recorded | 2 |
Histological characteristics | Atypical medullary | Lobular | Ductal | Ductal | Ductal |
Size (mm) | 5.2 | 20 | 10, 14, 10 (X3 separate foci) | 1.8 | 5 |
Grade | 3 | 3 | 3 | 3 | 3 |
ER status | Negative | Negative | Negative | Negative | Negative |
PR status | Negative | Negative | Negative | Negative | Negative |
Nodes | Negative | Negative | Negative | Negative | Negative |
Ductal lavage | |||||
Previous (months) | 5 | 1 | 5 | 12 | 4 |
No. ducts cannulated/breast | 1 (X1occ) | 2 (X1occ) | 1 (X2occ) | 1 (X1occ) | Unsuccessful |
Cell count (duct)/ml | 6,666 | 2,500, 6,666 | 47,700 + 4,000 | 15,000 | |
Total cell count (duct) | 79,992 | 35,000, 93,324 | 525,555 + 40,000 | 180,000 | |
Cytology score | Mild atypia | Benign | Benign | No epithelial cells | |