Figure 2
In vivo effect of asPR on progestin-independent tumor growth. (a) Effect of two different antiprogestins on tumor growth. Animals bearing tumors of size 25–50 mm2 were treated with RU 486 (6.5 mg/kg body weight) or ZK 299 (10 mg/kg body weight subcutaneously) or saline. (b) Tumor growth in animals treated with saline (n = 7) or asPR (n = 3) administered in two daily doses of 1 mg intraperitoneally (*P < 0.05). The differences in tumor growth rate are significantly different (P < 0.01). Inset: tumor weight at the end of the experiment, 11 days after treatment was initiated. (c,d) Effect of asPR (1 mg/12 hours, intraperitoneally), scPR (1 mg/12 hours, intraperitoneally), or RU 486 (6.5 mg/kg body weight, subcutaneously) on in vivo tumor growth. The percentage of the tumor size calculated as the final tumor area/tumor area at the beginning of the experiment (100%) was evaluated on the last day of treatment (panel b) or throughout 5 days of treatment (panel c). asPR, antisense oligodeoxynucleotides to progesterone receptors; scPR, scrambled oligodeoxynucleotides to progesterone receptors. asPR, antisense oligodeoxynucleotides to progesterone receptors; scPR, scrambled oligodeoxynucleotides to progesterone receptors.