Table 1 Dominant transforming growth factor-β gene signatures in the luminal MCF-7 CN and MCF-7 H2 cell lines
Sequence namea | Sequence descriptionb | Fold Δ MCF-7 CNc | Fold Δ MCF-7 H2d | Gene ontologye |
|---|---|---|---|---|
TGF-β induced genes | ||||
BCL3 | B-cell chronic lymphocytic Leukemia (CLL)/lymphoma 3 | 1.70 | Cell cycle | |
BACE | Beta-site amyloid precursor protein (APP)-cleaving enzyme | 2.86 | ECM/adhesion | |
CD59 | CD59 antigen p18-20 | 1.74 (3) | ECM/adhesion | |
CDH11 | Cadherin 11, type 2, OB-cadherin (osteoblast) | 1.94 | ECM/adhesion | |
COL18A1 | Collagen, type XVIII, alpha 1 | 1.91 | ECM/adhesion | |
COL5A1 | Collagen, type V, alpha 1 | 5.01 (2) | 4.22 (2) | ECM/adhesion |
IGSF4 | Immunoglobulin superfamily, member 4 | 1.94 | 1.81 | ECM/adhesion |
SCARB1 | Scavenger receptor class B, member 1 | 1.77 | ECM/adhesion | |
SPOCK | Sparc/osteonectin (testican) | 8.23 | ECM/adhesion | |
THBS1 | Thrombospondin 1 | 2.31 (3) | ECM/adhesion | |
BMP7 | Bone morphogenetic protein 7 (osteogenic protein 1) | 2.05 | Secreted factor | |
IGFBP5 | Insulin-like growth factor binding protein 5 | 4.56 | Secreted factor | |
MSMB | microseminoprotein, beta- | 11.19 (2) | 3.65 (2) | Secreted factor |
CBFA2T3 | Core-binding factor, runt domain, alpha subunit 2 | 2.06 | Transcription factor | |
DZIP3 | Zinc finger DAZ interacting protein 3 | 1.93 | Transcription factor | |
ELK3 | Sapiens cDNA: FLJ22425 fis, clone HRC08686 | 1.90 | Transcription factor | |
FOXO1A | Forkhead box O1A (rhabdomyosarcoma) | 3.45 (2) | Transcription factor | |
MADH3 | MAD, mothers against decapentaplegic homolog 3 | 4.77 | Transcription factor | |
NRBP | Nuclear receptor binding protein | 2.12 | Transcription factor | |
PLU-1 | Putative DNA/chromatin binding motif | 1.75 (2) | Transcription factor | |
SOLH | Small optic lobes homolog (Drosophila) | 1.86 | Transcription factor | |
TGIF | Transforming growth factor beta (TGFB)-induced factor (TALE family homeobox) | 1.70 | Transcription factor | |
TIEG | Transforming growth factor beta (TGFB) inducible early growth response | 1.77 | Transcription factor | |
TGF-β repressed genes | ||||
BIRC5 | Baculoviral inhibitor of apoptosis (IAP) repeat-containing 5 (survivin) | -3.04 | Apoptosis | |
CCNA2 | Cyclin A2 | -2.18 | Cell cycle | |
CCNB1 | Cyclin B1 | -1.99 | Cell cycle | |
CCNB2 | Cyclin B2 | -1.94 | Cell cycle | |
CCNE2 | Cyclin E2 | -2.03 | Cell cycle | |
CDC2 | Cell division cycle 2, G1 to S and G2 to M | -2.62 (2) | -1.77 (2) | Cell cycle |
CDC20 | CDC20 cell division cycle 20 homolog (S. cerevisiae) | -2.10 | Cell cycle | |
CDC25C | Cell division cycle 25C | -2.02 | Cell cycle | |
CDKN2C | Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | -2.59 | Cell cycle | |
CDKN3 | Cyclin-dependent kinase inhibitor 3 | -2.66 | Cell cycle | |
CKS1B | CDC28 protein kinase regulatory subunit 1B | -1.96 | Cell cycle | |
CKS2 | CDC28 protein kinase regulatory subunit 2 | -1.70 | Cell cycle | |
MKI67 | Antigen identified by monoclonal antibody Ki-67 | -2.26 (2) | -2.84 | Cell cycle |
MPHOSPH9 | M-phase phosphoprotein 9 | -1.86 | Cell cycle | |
NEK2 | NIMA (never in mitosis gene a)-related kinase 2 | -2.93 | Cell cycle | |
ASPM | asp (abnormal spindle)-like, microcephaly associated | -2.48 | Chromosome reg. | |
BUB1 | BUB1 budding uninhibited by benzimidazoles 1 homolog | -2.08 | -1.72 | Chromosome reg. |
BUB1B | BUB1 budding uninhibited by benzimidazoles 1 homolog β | -1.78 | Chromosome reg. | |
CENPA | Centromere protein A, 17 kDa | -2.53 | Chromosome reg. | |
CENPE | Centromere protein E, 312kDa | -9.38 | -4.87 | Chromosome reg. |
CENPF | Centromere protein F, 350/400 kDa (mitosin) | -2.42 | Chromosome reg. | |
CNAP1 | Chromosome condensation-related Structural maintenance of chromosomes (SMC)-associated protein 1 | -1.99 | Chromosome reg. | |
ESPL1 | Extra spindle poles like 1 (S. cerevisiae) | -2.62 | Chromosome reg. | |
HCAP-G | Chromosome condensation protein G | -2.29 (2) | -1.90 | Chromosome reg. |
HEC | Highly expressed in cancer, rich in leucine heptad repeats | -4.35 | -2.32 | Chromosome reg. |
PRC1 | Protein regulator of cytokinesis 1 | -2.23 | Chromosome reg. | |
SMC2L1 | SMC2 structural maintenance of chromosomes 2-like 1 | -3.27 | -1.70 | Chromosome reg. |
ZWINT | ZW10 interactor | -1.75 | Chromosome reg. | |
BARD1 | BRCA1 associated RING domain 1 | -1.92 | DNA metabolism | |
BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -1.71 | DNA metabolism | |
CDT1 | DNA replication factor | -1.70 | DNA metabolism | |
PIR51 | RAD51-interacting protein | -2.17 | DNA metabolism | |
POLD1 | Polymerase (DNA directed), delta 1, catalytic subunit | -2.68 | DNA metabolism | |
POLE2 | Polymerase (DNA directed), epsilon 2 (p59 subunit) | -1.78 | DNA metabolism | |
PRIM1 | Primase, polypeptide 1, 49 kDa | -1.76 | DNA metabolism | |
RAD51C | RAD51 homolog C (S. cerevisiae) | -1.72 | DNA metabolism | |
RFC4 | Replication factor C (activator 1) 4, 37 kDa | -1.72 | DNA metabolism | |
TOP2A | Topoisomerase (DNA) II alpha 170 kDa | -2.68 (2) | DNA metabolism | |
ID1 | Inhibitor of DNA binding 1, dominant negative HLH protein | -1.74 | Transcription factor | |
MXD3 | MAX dimerization protein 3 | -22.10 | Transcription factor | |
MYBL1 | v-myb myeloblastosis viral oncogene homolog-like 1 | -2.09 | Transcription factor | |
MYBL2 | v-myb myeloblastosis viral oncogene homolog-like 2 | -2.07 | Transcription factor |