Figure 4

Glucocorticoid and androgenic activity of the synthetic progestins and Dexamethasone. HeLa cells (GR⁺, PR^-, AR^-) were transfected with or without an AR expression vector, PRE₂/luciferase construct and Renilla control, and treated for 20 hours with 10 nmol/l MPA, R5020, DHT, or dexamethasone. Relative luciferase activity was measured. Stippled bars are GR⁺ cells lacking AR; grey bars are GR⁺ and AR⁺ cells. AR, androgen receptor; DEX, dexamethasone; DHT, dihydrotestosterone; GR, glucocorticoid receptor; MPA, medroxyprogesterone acetate; PR, progesterone receptor; RLU, relative luciferase units.