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Table 5 Comparison of ESEfinder and Rescue-ESE programs for identification of potential ESEs in exons 2–10 of the BRCA1 gene

From: Evolutionary conservation analysis increases the colocalization of predicted exonic splicing enhancers in the BRCA1gene with missense sequence changes and in-frame deletions, but not polymorphisms

 

ESEs predicted by ESEfinder

ESEs predicted by Rescue-ESE

ESEs predicted by both programs

Proportion of ESEfinder predicted ESEs also detected by Rescue-ESE

BRCA1 exons 2–10 (total)

47

116

11

23%

BRCA1 exons 2–10 (conserved or shared ESEs between human and mouse)

20

69

9

45%

BRCA1 exons 2–10 (conserved or shared ESEs between human and mouse affected by breast cancer associated sequence changes)

16

16

3

19%

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Breast Cancer Research

ISSN: 1465-542X

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