Figure 1From: Clioquinol and pyrrolidine dithiocarbamate complex with copper to form proteasome inhibitors and apoptosis inducers in human breast cancer cellsCopper complex formation as indicated by color change. (a) Chemical structures of compounds referenced in the text: 5,7-DiCl-8-OHQ, 5,7-dichloro-8-hydroxyquinoline; 8-OHQ, 8-hydroxyquinoline; CQ, clioquinol; PDTC, pyrrolidine dithiocarbamate. (b) 50 mM of PDTC, CQ, or tetrathiomolybdate (TM) were mixed in a 1:1 molar ratio with CuCl2. All solutions were made in dimethylsulfoxide. In each case the appearance of intensified color indicated formation of a copper complex.Back to article page