Table 3 Odds ratios and 95% confidence intervals for associations of SULT1A1 and UGT1A1 genotypes with breast cancer phenotypes

High-activity SULT1A1 genotype^a

Other SULT1A1 genotypes

Age at diagnosis

<60 years

57 (66.28%)

48 (53.33%)

1.85^d

1.00–3.45^d

0.08

≥60 years

29 (33.72%)

42 (46.67%)

Tumor size

≤2 cm

54 (71.05%)

33(51.56%)

2.63^e

1.25–5.56^e

0.02

>2 cm

22 (28.95%)

31 (48.44%)

Tumor grade

1

20 (25.32%)

16 (22.86%)

2 or 3

59 (74.68%)

54 (77.14%)

1.36^e

0.52–2.50^e

0.73

Low-activity UGT1A1 genotypes^b

Other UGT1A1 genotypes

Age at diagnosis

<60 years

6 (31.58%)

112 (61.88%)

≥60 years

13 (68.42%)

69 (38.12%)

3.70^d

1.33–10.00^d

0.01

Tumor size

≤2 cm

12 (70.59%)

86 (61.87%)

1.42^e

0.45–4.44^e

0.48

>2 cm

5 (29.41%)

53 (38.13%)

Tumor grade

1

4 (21.05%)

40 (26.85%)

2 or 3

15 (78.95%)

109 (73.15%)

3.70^e

1.33–10.00^e

0.59

SULT1A1 and UGT1A1 high-activity genotypes^c

Other SULT1A1 and UGT1A1 genotypes

Age at diagnosis

<60 years

20 (57.14%)

82 (59.85%)

1.10^d

0.52–2.35^d

0.77

≥60 years

15 (42.86%)

55 (40.15%)

Tumor size

≤2 cm

19 (70.37%)

67 (59.82%)

1.79^e

0.69–4.55^e

0.31

>2 cm

8 (29.63%)

45 (40.18%)

Tumor grade

1

11 (37.93%)

24 (20.51%)

2.56^e

1.04–6.25^e

0.05

2 or 3

18 (62.07%)

93 (79.49%)

Associations in the group of ER-negative tumors^f

High-activity SULT1A1 genotype^a

Other SULT1A1 genotypes

Age at diagnosis

<60 years

21 (91.30%)

12 (60.00%)

7.14^d

1.23–50^d

0.02

≥60 years

2 (8.70%)

8 (40.00%)

Tumor size

≤2 cm

18 (78.26%)

7 (41.18%)

14.28^e

2.17–100^e

0.02

>2 cm

5 (21.74%)

10 (58.82%)

SULT1A1 and UGT1A1 high-activity genotypes^c

Other SULT1A1 and UGT1A1 genotypes

Tumor size

≤2 cm

22 (73.33%)

3 (30.00%)

9.02^e

1.59–51.31^e

0.01

>2 cm

8 (26.67%)

7 (70.00%)

Tumor grade

1

3 (37.50%)

3 (8.82%)

10.00^e

1.09–100^e

0.04

2 or 3

5 (62.50%)

31 (91.18%)

Associations in the group of ER-positive tumors^f

Low-activity UGT1A1 genotypes^b

Other UGT1A1 genotypes

Age at diagnosis

<60 years

1 (14.29%)

47 (60.26%)

≥60 years

6 (85.71%)

31 (39.74%)

9.09^d

1.08–100^d

0.02