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Table 1 Effect of ovarian ablation in mice on MIN-O growth in fat pads

From: Selective estrogen receptor modulators inhibit growth and progression of premalignant lesions in a mouse model of ductal carcinoma in situ

Mice

MIN-O size at 5 weeks after transplantation

Tumor latency

 

%FPF (no.)

Relative to control

P

TE50 (weeks)

P

Control

67.50 ± 12.58 (4)

1

0.0001

6.60

0.0001

Ovariectomized

22.86 ± 7.56 (7)

0.34

 

10.10

 
  1. %FPF, percentage of fat pad filled; MIN-O, mammary intraepithelial neoplasia outgrowth; TE50, time for 50% of the transplanted mammary fat pads to produce palpable tumors.
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Breast Cancer Research

ISSN: 1465-542X

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