Early detection of breast cancer based on gene-expression patterns in peripheral blood cells

Sharma, Praveen; Sahni, Narinder S; Tibshirani, Robert; Skaane, Per; Urdal, Petter; Berghagen, Hege; Jensen, Marianne; Kristiansen, Lena; Moen, Cecilie; Sharma, Pradeep; Zaka, Alia; Arnes, Jarle; Sauer, Torill; Akslen, Lars A; Schlichting, Ellen; Børresen-Dale, Anne-Lise; Lönneborg, Anders

doi:10.1186/bcr1203

Breast Cancer Research

Table 1 Gene-expression patterns in 60 blood samples obtained from 56 different women

From: Early detection of breast cancer based on gene-expression patterns in peripheral blood cells

Subgroup A1: Women with breast cancer
Sample ID	Age (y)	Stage	Histology	Grade	Size (mm)	Nodes	Comments/ other disease if present	Times assayed	Prediction (37 genes)
3	54	I	IDC	1	11	0	#	2	+
5	67	0	DCIS	2	20	0	#	3	+
7	51	II	IDC	3	20	1/7	#	2	+
8	84	II	IDC	1	22	2/2	#	2	+
15	66	I	IDC	2	15	0	Rheumatic disease	3	+
16	68	I	IDC	1	7	0	#	1	+
17	66	II	IDC	1	26	0	Epilepsy	1	-
27	48	I	IDC	2	4	0	#	2	ND
31	47	I	IDC	2	15	0	#	2	-
35	44	II	IDC	2	25	0	#	1	+
36	50	I	Multifocal IDC	1	5 × 14	0	#	1	-
38	n.a.	0	DCIS	2	9	0	#	1	+
39	65	I	IDC	1	15	0	#	1	+
40	n.a.	I	IDC	2	14	0	Psoriasis	1	+
42	71	I	IDC	1	8	0	#	1	+
44	55	III	IDC	1	35	0	#	1	+
45	63	II	IDC	3	23	0	#	1	-
48	65	IV	-	-	-	Metastases in supra- and infra- clavicular nodes	Breast cancer, 1982	1	-
49	65	I	IDC	1	11	0	Type 2 diabetes	3	+
50	69	III	ILC	2	50	2/19	#	2	-
51	50	II	IDC	2	24	0	#	2	+
53	60	II	IDC	2	23	0	#	2	+
59	63	I	IDC	1	10	0	#	2	+
60	52	I	IDC	1	3	0	#	2	+
Subgroup A2: Women with abnormal first mammography
Sample ID	Age (y)	Breast abnormality					Comments / other disease if present	Times assayed	Prediction (37 genes)
1	44	Benign density					#	2	+
2	53	Benign microcalcifications					Encapsulated cyst in left knee	2	+
4	45	Benign density					#	2	+
11	46	Benign density					Ulcerative colitis since 1983	2	+
12	44	Benign density					#	2	+
13	50	Benign density					Type 1 diabetes	2	+
14	47	Benign microcalcifications					#	2	+
19	46	Benign density, cyst					Crohn's disease	2	+
20	n.a.	Benign density					Rheumatic disease	1	+
28	44	Benign microcalcifications					#	2	+
29	63	Benign density, cyst					Fibromyalgia	2	ND
30	46	Benign density					#	2	+
32	59	Benign tumor, fibroadenoma					#	2	+
34	45	Benign density					Type 2 diabetes	2	+
41	50	Fibrosis, benign					Size histology 60 mm	1	+
43	51	Radial scar					Size histology 10 mm	1	+
52	47	Benign density					#	2	ND
54	52	Benign microcalcifications					Cancer, large intestine, 1992	1	+
58	46	Benign density					#	2	+
Subgroup A3: Women with no reported breast abnormality
Sample ID	Age (y)						Comments	Times assayed	Prediction (37 genes)
6	42						#	3	+
9	30						Breast feeding	2	+
10	34						Breast feeding	3	+
21	26						#	1	+
22	-						#	1	+
18*	18						Week 1	2	+
23*							Week 2	1	+
24*							Week 3	1	+
26*							Week 4	2	+
25*							Week 5	1	+
33	34						Pregnant, 8 months	3	-
37	51						Acute bacterial infection in addition to chronic Epstein–Barr virus infection	1	-
46	27						Pregnant, 6 months	1	-
47	29						Pregnant, 9 months	1	-
55	43						#	1	+
56	43						#	2	+
57	22						#	2	+

Sample detail. Stage 0, in situ carcinoma; Stage I, invasive carcinoma with tumor size <20 mm; Stage II, invasive carcinoma with tumor size >20-50 mm; Stage III, invasive carcinoma with tumor size >50 mm. Stage IV, cancer spread to distant parts. *, Blood samples taken on five consecutive weeks from the same woman; -, incorrectly predicted; #, no relevant information available; +, correctly predicted; DCIS, ductal carcinoma in situ; IDC, invasive ductal carcinoma; ILC, invasive lobular carcinoma; n.a., not available; ND, nondecision.

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ISSN: 1465-542X

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