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Table 1 Gene-expression patterns in 60 blood samples obtained from 56 different women

From: Early detection of breast cancer based on gene-expression patterns in peripheral blood cells

Subgroup A1: Women with breast cancer
Sample ID Age (y) Stage Histology Grade Size (mm) Nodes Comments/ other disease if present Times assayed Prediction (37 genes)
3 54 I IDC 1 11 0 # 2 +
5 67 0 DCIS 2 20 0 # 3 +
7 51 II IDC 3 20 1/7 # 2 +
8 84 II IDC 1 22 2/2 # 2 +
15 66 I IDC 2 15 0 Rheumatic disease 3 +
16 68 I IDC 1 7 0 # 1 +
17 66 II IDC 1 26 0 Epilepsy 1 -
27 48 I IDC 2 4 0 # 2 ND
31 47 I IDC 2 15 0 # 2 -
35 44 II IDC 2 25 0 # 1 +
36 50 I Multifocal IDC 1 5 × 14 0 # 1 -
38 n.a. 0 DCIS 2 9 0 # 1 +
39 65 I IDC 1 15 0 # 1 +
40 n.a. I IDC 2 14 0 Psoriasis 1 +
42 71 I IDC 1 8 0 # 1 +
44 55 III IDC 1 35 0 # 1 +
45 63 II IDC 3 23 0 # 1 -
48 65 IV - - - Metastases in supra- and infra- clavicular nodes Breast cancer, 1982 1 -
49 65 I IDC 1 11 0 Type 2 diabetes 3 +
50 69 III ILC 2 50 2/19 # 2 -
51 50 II IDC 2 24 0 # 2 +
53 60 II IDC 2 23 0 # 2 +
59 63 I IDC 1 10 0 # 2 +
60 52 I IDC 1 3 0 # 2 +
Subgroup A2: Women with abnormal first mammography
Sample ID Age (y) Breast abnormality Comments / other disease if present Times assayed Prediction (37 genes)
1 44 Benign density # 2 +
2 53 Benign microcalcifications Encapsulated cyst in left knee 2 +
4 45 Benign density # 2 +
11 46 Benign density Ulcerative colitis since 1983 2 +
12 44 Benign density # 2 +
13 50 Benign density Type 1 diabetes 2 +
14 47 Benign microcalcifications # 2 +
19 46 Benign density, cyst Crohn's disease 2 +
20 n.a. Benign density Rheumatic disease 1 +
28 44 Benign microcalcifications # 2 +
29 63 Benign density, cyst Fibromyalgia 2 ND
30 46 Benign density # 2 +
32 59 Benign tumor, fibroadenoma # 2 +
34 45 Benign density Type 2 diabetes 2 +
41 50 Fibrosis, benign Size histology 60 mm 1 +
43 51 Radial scar Size histology 10 mm 1 +
52 47 Benign density # 2 ND
54 52 Benign microcalcifications Cancer, large intestine, 1992 1 +
58 46 Benign density # 2 +
Subgroup A3: Women with no reported breast abnormality
Sample ID Age (y)       Comments Times assayed Prediction (37 genes)
6 42       # 3 +
9 30       Breast feeding 2 +
10 34       Breast feeding 3 +
21 26       # 1 +
22 -       # 1 +
18* 18       Week 1 2 +
23*        Week 2 1 +
24*        Week 3 1 +
26*        Week 4 2 +
25*        Week 5 1 +
33 34       Pregnant, 8 months 3 -
37 51       Acute bacterial infection in addition to chronic Epstein–Barr virus infection 1 -
46 27       Pregnant, 6 months 1 -
47 29       Pregnant, 9 months 1 -
55 43       # 1 +
56 43       # 2 +
57 22       # 2 +
  1. Sample detail. Stage 0, in situ carcinoma; Stage I, invasive carcinoma with tumor size <20 mm; Stage II, invasive carcinoma with tumor size >20-50 mm; Stage III, invasive carcinoma with tumor size >50 mm. Stage IV, cancer spread to distant parts. *, Blood samples taken on five consecutive weeks from the same woman; -, incorrectly predicted; #, no relevant information available; +, correctly predicted; DCIS, ductal carcinoma in situ; IDC, invasive ductal carcinoma; ILC, invasive lobular carcinoma; n.a., not available; ND, nondecision.