- Poster Presentation
Association of NCOA3 (AIB1) polymorphisms with breast cancer risk
Breast Cancer Research volume 7, Article number: P1.20 (2005)
The nuclear receptor coactivator 3 (NCOA3, also known as AIB1) is a coactivator of nuclear receptors like the estrogen receptor. NCOA3 is overexpressed in ~60% of primary human breast tumours, and high levels of NCOA3 expression are associated with tamoxifen resistance and worse survival rate. In contrast, NCOA3 deficiency suppresses v-Ha-ras-induced breast cancer initiation and progression in mice. Here we analysed the influence of NCOA3 coding single nucleotide polymorphisms on breast cancer risk by performing a case–control study using a German and a Polish study population, and identified an association between NCOA3 polymorphisms and breast cancer. A joint analysis of the German and Polish study population revealed a significant protective effect for the 1758G>C (Q586H) and 2880A>G (T960T) variants. In addition, haplotype analysis showed a protective effect of the 1758C-2880A and 1758G-2880G haplotypes (odds ratio = 0.79, 95% confidence interval = 0.67-0.93, P = 0.004). Due to the impact of NCOA3 in anti-estrogen therapy resistance, these polymorphisms might also influence therapy outcome in breast cancer.
BB and MW contributed equally to this work.
About this article
Cite this article
Burwinkel, B., Wirtenberger, M., Frank, B. et al. Association of NCOA3 (AIB1) polymorphisms with breast cancer risk. Breast Cancer Res 7, P1.20 (2005). https://doi.org/10.1186/bcr1107
- Breast Cancer
- Breast Cancer Risk
- Nuclear Receptor
- Human Breast Tumour