Genotype | Cases, n (%) | Controls, n (%) | Crude OR (95% CI) | Adjusted OR (95% CI)a |
---|---|---|---|---|
Premenopausal | Â | Â | Â | Â |
A 1/A 1 (TT) | 414 (40) | 201 (38) | 1.00 | 1.00 |
A 1/A 2 (TC) | 460 (44) | 253 (48) | 0.88 (0.70, 1.11) | 0.90 (0.71, 1.14) |
A 2/A 2 (CC) | 169 (16) | 75 (14) | 1.09 (0.79, 1.51) | 1.08 (0.78, 1.51) |
Postmenopausal | Â | Â | Â | Â |
A 1/A 1 (TT) | 99 (41) | 66 (44) | 1.00 | 1.00 |
A 1/A 2 (TC) | 105 (44) | 64 (43) | 1.09 (0.70, 1.70) | 1.32 (0.82, 2.12) |
A 2/A 2 (CC) | 37 (15) | 20 (13) | 1.23 (0.66, 2.31) | 1.29 (0.66, 2.52) |
Pooled | Â | Â | Â | Â |
A 1/A 1 (TT) | 513 (40) | 267 (39) | 1.00 | 1.00 |
A 1/A 2 (TC) | 565 (44) | 317 (47) | 0.93 (0.76, 1.14) | 0.96 (0.77, 1.18) |
A 2/A 2 (CC) | 206 (16) | 95 (14) | 1.13 (0.85, 1.50) | 1.12 (0.83, 1.51) |
No family historyb | Â | Â | Â | Â |
A 1/A 1 (TT) | 462 (40) | 249 (39) | 1.00 | 1.00 |
A 1/A 2 (TC) | 501 (44) | 296 (47) | 0.91 (0.74, 1.13) | 0.95 (0.76, 1.18) |
A 2/A 2 (CC) | 182 (16) | 91 (14) | 1.08 (0.80, 1.45) | 1.10 (0.81, 1.49) |
With family historyb | Â | Â | Â | Â |
A 1/A 1 (TT) | 51 (37) | 18 (42) | 1.00 | 1.00 |
A 1/A 2 (TC) | 64 (46) | 21 (49) | 1.08 (0.52, 2.23) | 1.08 (0.49, 2.36) |
A 2/A 2 (CC) | 24 (17) | 4 (9) | 2.12 (0.65, 6.94) | 2.46 (0.70, 8.60) |