Table 1 Genotype frequencies of 53BP1 polymorphisms in breast cancer patients and controls
From: TP53-binding protein variants and breast cancer risk: a case-control study
Polymorphism | No. (%) of cases | No. (%) of controls | AOR (95% CI) | P |
|---|---|---|---|---|
D353E (1059C>G) | ||||
CC | 165 (48.1) | 453 (47.6) | ||
GC | 148 (43.1) | 405 (42.5) | ||
GG | 30 (8.7) | 94 (9.9) | ||
Σ | 343 | 952 | ||
CC vs GC+GG | 1.07 (0.81–1.43) | 0.62 | ||
G412S (1234G>A) | ||||
GG | 269 (78.7) | 760 (80.1) | ||
AG | 67 (19.6) | 174 (18.3) | ||
AA | 6 (1.8) | 15 (1.6) | ||
Σ | 342 | 949 | ||
AA+AG vs GG | 1.22 (0.86–1.74) | 0.26 | ||
1347_1352delTATCCC | ||||
wt/wt | 334 (98.2) | 931 (97.4) | ||
delTATCCC/wt | 6 (1.8) | 25 (2.6) | ||
delTATCCC/delTATCCC | 0 (0.0) | 0 (0.0) | ||
Σ | 340 | 956 | ||
delTATCCC/wt vs wt/wt | 0.61 (0.22–1.68) | 0.34 | ||
K1136Q (3406A>C) | ||||
AA | 158 (47.4) | 448 (47.8) | ||
CA | 144 (43.2) | 396 (42.2) | ||
CC | 31 (9.3) | 94 (10.0) | ||
Σ | 333 | 938 | ||
CC+CA vs AA | 1.10 (0.82–1.47) | 0.53 |