Table 2 Distribution of breast cancer risk factors according to CYP17 genotype for premenopausal women in Germany
Patient characteristics | CYP17 genotype | |||||
|---|---|---|---|---|---|---|
A1/A1 (n = 503) | A1/A2 (n = 668) | A2/A2 (n = 260) | ||||
Cases, no. (%) | Controls no. (%) | Cases, no. (%) | Controls no. (%) | Cases, no. (%) | Controls no. (%) | |
Age at menarche (years)a | ||||||
<13 | 68 (37.8) | 123 (38.2) | 84 (34.4) | 149 (35.1) | 34 (33.0) | 51 (32.5) |
≥13 | 112 (62.2) | 199 (61.6) | 158 (64.8) | 275 (64.9) | 68 (66.0) | 106 (67.5) |
Age at first full-term pregnancy (years)b | ||||||
<25 | 69 (49.6) | 125 (49.4) | 106 (56.1) | 172 (52.1) | 40 (53.3) | 55 (45.1) |
≥25 | 70 (50.4)) | 128(50.6) | 83 (43.9) | 158 (47.9) | 35 (46.7) | 67 (54.9) |
Parity | ||||||
0 birth | 41 (22.8) | 70 (21.7) | 55 (22.5) | 94 (22.2) | 28 (27.2) | 35 (22.3) |
1–2 births | 123 (68.3) | 201 (62.2) | 168 (68.9) | 260 (61.3) | 63 (61.2) | 96 (61.1) |
>2 births | 16 (8.9) | 52 (16.1) | 21 (8.6) | 70 (16.5) | 12 (11.6) | 26 (16.6) |
Total months of breastfeedingb | ||||||
0 | 43 (30.9) | 65 (25.7) | 53 (28.0) | 94 (28.5) | 20 (26.7) | 28 (22.9) |
1–12 | 86 (61.9) | 156 (61.7) | 117 (61.9) | 186 (56.4) | 50 (66.8) | 74 (60.7) |
>12 | 10 (7.2) | 32 (12.6) | 19 (10.1) | 50 (15.2) | 5 (6.7) | 20 (16.4) |
Ever use oral contraceptivec | ||||||
No | 30 (17.1) | 62 (19.4) | 31 (13.0) | 84 (20.0)* | 24 (23.3) | 32 (20.5) |
Yes | 146 (82.9) | 258 (80.6) | 207 (87.0) | 336 (80.0) | 79 (76.7) | 124 (79.5) |
Family history of breast cancer in first-degree relative | ||||||
No | 150 (83.3) | 306 (94.7)* | 217 (88.9) | 407 (96.0) | 95 (92.2) | 143 (91.1) |
Yes | 30 (16.7) | 17 (5.3) | 27 (11.1) | 17 (4.0) | 8 (7.8) | 14 (8.9) |
Current BMI (k/m2)d | ||||||
<20.0 | 26 (14.4) | 35 (10.8) | 39 (16.0) | 47 (11.1) | 10 (9.7) | 25 (15.9) |
20.0–25.0 | 95 (52.8) | 191 (59.1) | 130 (53.3) | 245 (57.8) | 64 (62.1)) | 87 (55.4) |
25.1–30.0 | 38 (21.1) | 71 (22.0) | 51 (20.9) | 95 (22.4) | 20 (19.4) | 30 (19.1) |
>30.0 | 20 (11.1) | 25 (7.7) | 24 (9.8) | 37 (8.7) | 9 (8.7) | 15 (9.6) |
Educational level | ||||||
Low | 24 (13.4) | 39 (12.1) | 31 (12.7) | 50 (11.8) | 16 (15.5) | 17 (10.8) |
Middle | 114 (63.3) | 200 (61.9) | 159 (65.2) | 262 (61.8) | 63 (61.2) | 87 (55.4) |
High | 42 (23.3) | 84 (26.0) | 54 (22.1) | 112 (26.4) | 24 (23.3) | 53 (33.8) |
Alcohol consumption (g/day) | ||||||
0 | 39 (21.7) | 52 (16.1)* | 52 (21.3) | 72 (17.0) | 18 (17.5) | 24 (15.3) |
1–18 | 118 (65.5) | 246 (76.2) | 158 (64.8) | 309 (72.9) | 70 (68.0) | 119 (75.8) |
>18 | 23 (12.8) | 25 (7.7) | 34 (13.9) | 43 (10.1) | 15 (14.5) | 14 (8.8) |