Context
Breast cancer biology is regulated by members of the epidermal growth factor receptor (EGFR) family. Traditionally, effects of these plasma membrane-associated tyrosine kinase receptors have been attributed to the activation of multiple diverse intracellular signaling pathways. However, nuclear localization of the EGFR has been documented although the function of these nuclear receptors is uncertain. In this study, the authors suggest that nuclear EGFR may function as a transcription factor.