- Paper Report
- Open Access
Comparison of DCIS and post-surgical local recurrence
- Richard de Boer1
© Biomed Central Ltd 2001
- Received: 27 April 2001
- Accepted: 20 August 2001
- Published: 1 December 2001
- DCIS, HER2, local recurrence, p53
With the widespread use of mammographic screening, the detection of ductal carcinoma in situ (DCIS) has markedly increased. Surgery is the preferred treatment, and breast conserving surgery is increasingly used. Within the remaining breast tissue, true local recurrences (ie tumour left behind) or new primaries can develop. This study analysed the incidence of second primary tumours and the molecular similarities between the original DCIS and the recurrent disease.
Of 116 recurrences examined, 61 (53%) were DCIS and 55 (47%) were invasive. Of these 116, 103 (89%) occurred near the site of the original resection. Comparing the primary DCIS and the recurrence, concordant histology was found in 62%. Although 11% of the recurrences developed at a distance from the primary DCIS, nearly all these showed the same histological and immunohistochemical profile. Well differentiated DCIS progressed towards poorly differentiated DCIS or grade III invasive carcinoma in 4 cases, whilst in 5 cases poorly differentiated DCIS or grade I invasive carcinoma. Identical marker expression (oestrogen receptor and progesterone receptor status and HER2/neu and p53 overexpression) was found in 45 out of 71 (63%) cases assessed. As, in most cases, primary DCIS and local recurrence were closely related, either histologically or by marker expression, the authors concluded that local recurrence probably reflects outgrowth of residual DCIS.
Cases were obtained from the EORTC trial 10853, which compared treatment for DCIS with wide local excision versus excision plus radiotherapy; standard immunohistochemistry for oestrogen receptor, progesterone receptor, HER2/neu (3B5 monoclonal antibody), and p53 (D0-7 antibody); review of histology
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