Quantitative characterization of breast lesions and normal fibroglandular tissue using compartmentalized diffusion-weighted model: comparison of intravoxel incoherent motion and restriction spectrum imaging

He, Litong; Qin, Yanjin; Hu, Qilan; Liu, Zhiqiang; Zhang, Yunfei; Ai, Tao

doi:10.1186/s13058-024-01828-3

Table 4 The descriptive statistics of the mono-exponential, IVIM and RSI derived parameters

From: Quantitative characterization of breast lesions and normal fibroglandular tissue using compartmentalized diffusion-weighted model: comparison of intravoxel incoherent motion and restriction spectrum imaging

	Malignant	Benign	Healthy	χ² value	P value*	Z value (P value**)
	Malignant	Benign	Healthy	χ² value	P value*	Malignant vs. Benign	Malignant vs. Healthy	Benign vs. Healthy
Mono-ADC (×10^− 3 mm²/s)	0.955 ± 0.140	1.357 ± 0.367	1.362 ± 0.407	81.620	< 0.001	-6.714 (< 0.001)	-8.267 (< 0.001)	-0.219 (0.827)
IVIM-Dt (×10^− 3 mm²/s)	0.662 ± 0.106	0.940 ± 0.304	0.868 ± 0.420	31.310	< 0.001	-5.778 (< 0.001)	-4.111 (< 0.001)	-1.122 (0.262)
IVIM-Dp (mm²/s)	0.022 ± 0.006	0.019 ± 0.007	0.025 ± 0.007	27.008	< 0.001	-2.717 (0.007)	-3.117 (0.002)	-4.850 (< 0.001)
IVIM-f	0.235 ± 0.036	0.256 ± 0.059	0.213 ± 0.048	31.206	< 0.001	-2.546 (0.011)	-4.054 (< 0.001)	-4.675 (< 0.001)
RSI-C₁	0.540 ± 0.250	0.233 ± 0.195	0.119 ± 0.102	178.453	< 0.001	-6.334 (< 0.001)	-13.223 (< 0.001)	-3.157 (0.002)
RSI-C₂	1.826 ± 0.778	1.972 ± 1.0008	0.894 ± 0.444	127.860	< 0.001	-0.248 (0.804)	-10.477 (< 0.001)	-7.161 (< 0.001)
RSI-C₃	0.161 ± 0.159	0.329 ± 0.345	0.215 ± 0.110	29.935	< 0.001	-2.789 (0.005)	-5.494 (< 0.001)	-0.044 (0.965)
RSI-C₁C₂	1.151 ± 1.042	0.484 ± 0.535	0.078 ± 0.082	195.292	< 0.001	-5.083 (< 0.001)	-13.611 (< 0.001)	-5.878 (< 0.001)
RSI-F₁	0.209 ± 0.051	0.116 ± 0.068	0.184 ± 0.123	41.670	< 0.001	-7.045 (< 0.001)	-3.602 (< 0.001)	-3.117 (0.002)
RSI-F₂	0.737 ± 0.039	0.767 ± 0.069	0.665 ± 0.081	91.203	< 0.001	-3.089 (0.002)	-8.261 (< 0.001)	-6.689 (< 0.001)
RSI-F₃	0.079 ± 0.032	0.138 ± 0.085	0.182 ± 0.059	154.082	< 0.001	-4.076 (< 0.001)	-12.508 (< 0.001)	-3.925 (< 0.001)
RSI-F₁F₂	0.151 ± 0.032	0.088 ± 0.048	0.106 ± 0.060	67.776	< 0.001	-6.678 (< 0.001)	-7.081 (< 0.001)	-1.697 (0.090)

Note: Data are presented as mean ± SD. P values* are calculated by Kruskal-Wallis test, and a P value < 0.05 was considered statistically significant. P value** are calculated by Mann-Whitney U-test, and a P value < 0.0167 was considered statistically significant. Bolded text indicates statistical significance

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