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Fig. 8 | Breast Cancer Research

Fig. 8

From: Metabolomics assisted by transcriptomics analysis to reveal metabolic characteristics and potential biomarkers associated with treatment response of neoadjuvant therapy with TCbHP regimen in HER2 + breast cancer

Fig. 8

Integrated transcript and metabolite profile analysis. (A) Heatmap of the Spearman correlation coefficient matrix between the top 20 differentially expressed metabolites (DEMs) and the top 20 differentially expressed genes (DEGs). The red and blue colors represent a positive correlation and a negative correlation, respectively. The color label reflects the Spearman correlation coefficient value. (B) Cytoscape was used to construct the correlation network of the top 20 DEMs (red nodes) and the top 20 DEGs (green nodes). The results with P Value < 0.05 were shown. Positive and negative correlations are shown by the red and blue margins, respectively. (C)Venn diagram was used to identify the KEGG pathways in which both the DEMs and DEGs participated. (D) The histogram of KEGG pathways in which DEMs and DEGs are both enriched. (E) The DEMs involved in the integrated pathways. (F) The DEGs involved in the integrated pathways. DEMs were derived from 40 pre-therapeutic patients including 19 patients from non-pCR group and 21 patients from pCR group; DEGs were derived from nine patients including six patients from non-pCR group and three patients from pCR group. *P<0.05; ** P<0.01, ***P<0.001

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Breast Cancer Research

ISSN: 1465-542X

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