Fig. 5

Thirteen metabolites exhibited permanent changes between non-pCR patients and pCR patients during the therapy term. (A) Venn plot was performed to identify metabolites that were persistently and differentially expressed between non-pCR patients and pCR patients (A vs. D, B vs. E and C vs. F). (B-N) Violin plots depicting the levels of 13 metabolites between non-pCR and pCR groups at different treatment time points. The Kruskal Wallis test was used to compare the metabolite expression difference among multiple groups