| All patients (N = 871)a | ER + /LN + patients (N = 335)b | ER + /LN− patients (N = 374)b | |||||||
---|---|---|---|---|---|---|---|---|---|---|
Signature | N (%) | HR (95% CI) | P | N (%) | HR (95% CI) | P | N (%) | HR (95% CI) | P | |
Genomic grade index | ||||||||||
 GG1 | 453 (52) | 1 (−) | – | 169 (50) | 1 (−) | – | 234 (63) | 1 (−) | – | |
 GG3 | 418 (48) | 1.5 (1.1–2) | 0.01 | 166 (50) | 1.7 (1.1–2.6) | 0.01 | 140 (37) | 1.4 (0.8–2.4) | 0.22 | |
70-gene | ||||||||||
 Low risk | 479 (55) | 1 (−) | – | 186 (55) | 1 (−) | – | 249 (67) | 1 (−) | – | |
 High risk | 392 (45) | 1.7 (1.3–2.3) |  < 0.001 | 149 (45) | 1.6 (1.1–2.5) | 0.02 | 125 (33) | 1.9 (1.2–3.3) | 0.01 | |
Recurrence score | ||||||||||
 Low risk | 199 (23) | 1 (−) | – | 75 (23) | 1 (−) | – | 106 (28) | 1 (−) | – | |
 Intermediate risk | 211 (24) | 1.2 (0.8–2) | 0.41 | 98 (29) | 1.2 (0.7–2.3) | 0.51 | 102 (27) | 1.2 (0.6–2.6) | 0.62 | |
 High risk | 461 (53) | 2 (1.3–3.1) | 0.001 | 162 (48) | 2.4 (1.4–4.3) | 0.002 | 166 (45) | 1.6 (0.8—3.1) | 0.21 | |
Cell cycle score | ||||||||||
 Low | 329 (38) | 1 (−) |  | 118 (35) | 1 (−) | – | 166 (44) | 1 (−) | – | |
 Intermediate | 283 (32) | 1.7 (1.2–2.5) | 0.005 | 128 (38) | 1.7 (1–2.8) | 0.04 | 130 (35) | 2 (1–3.7) | 0.04 | |
 High | 259 (30) | 2.3 (1.5–3.5) |  < 0.001 | 89 (27) | 2.7 (1.6–4.7) |  < 0.001 | 78 (21) | 2.2 (1.1–4.4) | 0.02 | |
ROR-P | ||||||||||
 Low proliferation | 206 (24) | 1 (−) | – | 69 (21) | 1 (−) | – | 118 (32) | 1 (−) | – | |
 Int. proliferation | 532 (61) | 1.7 (1.1–2.6) | 0.03 | 236 (70) | 2.3 (1.2 – 4.5) | 0.01 | 221 (59) | 1.2 (0.7–2.3) | 0.49 | |
 High proliferation | 133 (15) | 3.2 (1.8–5.6) |  < 0.001 | 30 (9) | 5.6 (2.4–13.2) |  < 0.001 | 35 (9) | 2.7 (1.2–6.4) | 0.02 | |
PAM50 | ||||||||||
 Luminal A | 493 (57) | 1 (−) | – | 204 (61) | 1 (−) | – | 251 (67) | 1 (−) | – | |
 Luminal B | 206 (24) | 1.5 (1.1–2.1) | 0.02 | 94 (28) | 1.3 (0.8–2) | 0.26 | 88 (24) | 1.9 (1.1–3.3) | 0.02 | |
 Her2-enriched | 69 (8) | 1.6 (0.9–2.8) | 0.1 | 23 (7) | 1.4 (0.7–2.9) | 0.34 | 11 (3) | 2.1 (0.6–7.2) | 0.23 | |
 Basal-like | 65 (7) | 0.8 (0.3–2) | 0.65 | 5 (1) | 2.4 (0.6–10) | 0.23 | 5 (1) | 0.9 (0.1–6.7) | 0.92 | |
 Normal-like | 38 (4) | 0.7 (0.3–1.7) | 0.39 | 9 (3) | 0.5 (0.1–2.1) | 0.36 | 19 (5) | 0.4 (0.1–2.7) | 0.32 |