Fig. 3
From: The FBXW7-binding sites on FAM83D are potential targets for cancer therapy
Evaluation of the significance of residues H343/L344 for the oncogenic roles of FAM83D in vitro. a, The effects of H343/L344 mutation (FAM83D M2) on the BC cell viability were determined by CCK8 assay. b, The effects of H343/L344 mutation (FAM83D M2) on the BC cell proliferation were detected by clonogenic assay. Quantitative analyses were shown in the graphs. c-d, The effects of H343/L344 mutation (FAM83D M2) on the BC cell migration and invasion were determined by wound-healing assay (c) and Matrigel coated or uncoated Transwell assay (d). Quantitative analyses were shown in the graphs. Data were presented as mean ± SD. ns: not significant. **: p < 0.01, ***: p < 0.001 based on the Student’s t-test