Characteristics | Primary analysis cohort | Subgroup analysis cohort | |||
---|---|---|---|---|---|
1st-timepoint subgroup | 2nd-timepoint subgroup | ||||
n = 345a | n = 245 | p | n = 207 | p | |
Age (year), IQR | 51 (42, 58) | 51 (42, 58) | 0.865 | 50 (41, 58) | 0.427 |
Tumor size (mm), IQR | 37 (27, 49) | 36 (27, 49) | 0.786 | 37 (28, 49) | 0.965 |
Menopausal status | 0.595 | Â | 0.947 | ||
 Premenopausal | 174 (50) | 129 (53) |  | 105 (51) |  |
 Postmenopausal | 171 (50) | 116 (47) |  | 102 (49) |  |
TNM | 0.726 | Â | 0.839 | ||
 IIA | 64 (19) | 49 (20) |  | 33 (16) |  |
 IIB | 127 (37) | 79 (32) |  | 84 (41) |  |
 IIIA | 50 (15) | 33 (14) |  | 31 (15) |  |
 IIIB | 27 (7.8) | 24 (10) |  | 13 (6.3) |  |
 IIIC | 77 (22) | 60 (25) |  | 46 (22) |  |
Histologic grade | 0.619 | Â | 0.427 | ||
 2 | 239 (69) | 165 (67) |  | 150 (73) |  |
 3 | 106 (31) | 80 (33) |  | 57 (28) |  |
Molecular subtype | 0.747 | Â | 0.871 | ||
 HR+/HER2− | 151 (44) | 100 (41) |  | 94 (45) |  |
 HER2+ | 123 (36) | 94 (38) |  | 74 (36) |  |
 TNBC | 71 (21) | 51 (21) |  | 39 (19) |  |
NAT regimen | 0.763 | Â | 0.943 | ||
 Anthracycline-based | 29 (8.4) | 17 (7.1) |  | 16 (7.7) |  |
 Taxane-based | 123 (36) | 92 (38) |  | 76 (37) |  |
 Anthracycline and taxane-based | 193 (56) | 136 (56) |  | 115 (56) |  |
Treatment response | 0.855 | Â | 0.888 | ||
 pCR | 113 (33) | 82 (33) |  | 69 (33) |  |
 Non-pCR | 232 (67) | 163 (67) |  | 138 (67) |  |
FGT | 0.747 | Â | 0.787 | ||
 Scattered | 70 (20) | 51 (21) |  | 39 (19) |  |
 Heterogeneously | 211 (61) | 143 (58) |  | 125 (60) |  |
 Extremely dense | 64 (19) | 51 (21) |  | 43 (21) |  |
BPE | 0.860 | Â | 0.404 | ||
 Minimal | 35 (10) | 29 (12) |  | 14 (6.8) |  |
 Mild | 192 (56) | 139 (57) |  | 113 (55) |  |
 Moderate | 88 (26) | 58 (24) |  | 56 (27) |  |
 Marked | 30 (8.7) | 19 (7.8) |  | 24 (12) |  |
Enhancement type | 0.756 | Â | 0.716 | ||
 Mass | 281 (81) | 202 (82) |  | 166 (80) |  |
 Non-mass | 64 (19) | 43 (18) |  | 41 (20) |  |
Multiplicity | 0.521 | Â | 0.190 | ||
 Single lesion | 129 (37) | 98 (40) |  | 66 (32) |  |
 Multi-lesion | 216 (63) | 147 (60) |  | 141 (68) |  |
Shape | 0.491 | Â | 0.595 | ||
 Round or oval | 68 (20) | 54 (22) |  | 37 (18) |  |
 Irregular | 277 (80) | 191 (78) |  | 170 (82) |  |
Margin | 0.688 | Â | 0.735 | ||
 Circumscribed | 24 (7.0) | 15 (6.1) |  | 16 (7.7) |  |
 Not circumscribed | 321 (93) | 230 (94) |  | 191 (92) |  |
Kinetics | 0.962 | Â | 0.896 | ||
 Persistent | 8 (2.3) | 5 (2.0) |  | 4 (1.9) |  |
 Plateau | 123 (36) | 86 (35) |  | 71 (34) |  |
 Washout | 214 (62) | 154(63) |  | 132 (64) |  |