Fig. 2

Variable importance of random forest (model 4) in the X2101 + SOLAR-1 training set (A) and prognostic association of risk status based on a random forest model with fasting plasma glucose, BMI, HbA_1c, monocytes, and age (model 7) with time to grade 3/4 hyperglycemia event in the X2101 + SOLAR-1 training set (B) and the X2101 + SOLAR-1 test set (C). A was calculated by conditional permutation importance, B was calculated by cumulative incidence curves, and C was calculated using the Kaplan–Meier method. bid, twice daily dosing; BMI, body mass index; DBP, diastolic blood pressure; FPG, fasting plasma glucose; HDL, high-density lipoprotein cholesterol; RBC, red blood cells; SBP, systolic blood pressure.