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Fig. 7 | Breast Cancer Research

Fig. 7

From: ADAMTS18 deficiency associates extracellular matrix dysfunction with a higher risk of HER2-positive mammary tumorigenesis and metastasis

Fig. 7

Analysis of the protein levels of integrinα3 (ITGA3), α5 (ITGA5), β1(ITGB1), c-JUN, phosphorylated c-JUN (p–c-JUN), LOXL2 and MMP9 in mammary glands of 30-month-old mice. (A) Representative Western blot images of different proteins from the indicated genotypes (30-month-old Her2t/w/Adamts18+/+ and Her2t/w/Adamts18−/− mice). (B-G) Relative expression levels of the proteins are represented as p–c-JUN/c-JUN or protein/GAPDH. Each dot or square represents an individual. Data are expressed as mean ± SD (n = 4). *p < 0.05; **p < 0.01; ***p < 0.001; Student’s t-test, two tailed

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