Skip to main content

Table 4 Hazard ratio of contralateral breast cancer derived from univariate and multivariate cox regression model

From: Increased risk of contralateral breast cancer for BRCA1/2 wild-type, high-risk Korean breast cancer patients: a retrospective cohort study

Variable

Univariate

Multivariate (including family history)

Multivariate (excluding family history)

HR

[95% CI]

p value

HR

[95% CI]

p value

HR

[95% CI]

p value

Age

 Age > 40

1

  

1

  

1

  

 Age ≤ 40

1.68

[1.27, 2.22]

< 0.001

1.25

[0.85, 1.84]

0.26

0.98

[0.85, 1.84]

0.26

TNBC

 Yes

2.18

[1.66, 2.87]

< 0.001

1.69

[1.20, 2.40]

0.003

1.44

[1.02, 2.02]

0.036

Ovary cancer

 Yes

1.06

[0.15, 7.55]

0.955

      

First-degree relatives with BC

 Yes

2.92

[2.08, 4.08]

< 0.001

1.95

[1.23. 3.08]

0.004

   

 T stage

0.95

[0.79, 1.14]

0.575

      

 N stage

1.02

[0.88, 1.19]

0.796

      

 Histologic grade

1.16

[0.93, 1.44]

0.182

      

Endocrine therapy

 Yes

0.48

[0.37, 0.61]

< 0.001

      

BRCA test

 Low risk

1

  

1

  

1

  

 Not tested

2.19

[1.67, 2.86]

< 0.001

1.41

[0.92, 2.16]

0.115

1.88

[1.29, 2.76]

0.001

 BRCAx

2.77

[1.76, 4.35]

< 0.001

1.57

[0.84, 2.91]

0.154

2.6

[1.56, 1.33]

< 0.001

 BRCA mutation

7.3

[4.11, 13.0]

< 0.001

3.2

[1.44, 7.14]

0.004

6.17

[3.23, 11.8]

< 0.001

  1. TNBC triple negative breast cancer, HR hazard ratio, CI confidence interval, BC breast cancer
Back to article page

Breast Cancer Research

ISSN: 1465-542X

Contact us