Increased risk of contralateral breast cancer for BRCA1/2 wild-type, high-risk Korean breast cancer patients: a retrospective cohort study

Table 3 Hazard ratio of mortality from univariate and multivariate cox regression model

Variable	Univariate			Multivariate
Variable	HR	[95% CI]	p value	HR	[95% CI]	p value
Age
Age > 40	1
Age ≤ 40	1.33	[1.14, 1.55]	< 0.001
TNBC
Yes	2.43	[2.11, 2.79]	< 0.001	1.44	[1.16, 1.79]	< 0.001
Ovary cancer
Yes
First-degree relatives with BC
Yes	0.7	[0.51, 0.95]	0.023	0.84	[0.59, 1.18]	0.315
T stage	2.24	[2.09, 2.41]	< 0.001	1.56	[1.25, 1.95]	< 0.001
N stage	2.06	[1.93, 2.19]	< 0.001	1.71	[1.47, 1.75]	< 0.001
Histologic grade	1.08	[1.05, 1.11]	< 0.001
Endocrine therapy
Yes	0.37	[0.33, 0.42]	< 0.001	0.53	[0.44, 0.63]	< 0.001
BRCA test
Low risk	1			1
Not tested	1.46	[1.27, 1.68]	< 0.001	0.88	[0.74, 1.05]	0.165
BRCAx	1.18	[0.87, 1.58]	0.282	0.92	[0.66, 1.27]	0.611
BRCA mutation	1.76	[1.07, 2.89]	0.026	1.02	[0.59, 1.77]	0.944

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