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Table 3 Reclassification for BWHS predicted 5-year risk versus BWHS + PRS predicted 5-year risk

From: Addition of polygenic risk score to a risk calculator for prediction of breast cancer in US Black women

Cases

BWHS + PRS

Total

 < 1.66%

1.66–< 2.5%

 ≥ 2.5%

BWHS model only

 < 1.66%

503

94

23

620

 1.66–< 2.5%

72

134

74

280

 ≥ 2.5%

2

8

12

22

 Total

577

236

109

922

Controls

BWHS + PRS

Total

 < 1.66%

1.66–< 2.5%

 ≥ 2.5%

BWHS model only

 < 1.66%

1146

126

13

1285

 1.66–< 2.5%

185

245

106

536

 ≥ 2.5%

4

9

10

23

 Total

1335

380

129

1844

  1. Net reclassification improvement (95% CI) = 0.092 (0.065–0.119)
  2. For cases, reclassification = 0.118; for controls, reclassification = − 0.026
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Breast Cancer Research

ISSN: 1465-542X

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