Parameter | Amcenestrant 400 mg (n = 31) | Amcenestrant 200 mg (n = 35) | Letrozole (n = 29) |
---|---|---|---|
Ki67 (%) | |||
Baselinea | 29.7 | 28.6 | 29.4 |
Day 15a | 7.1 | 9.1 | 6.6 |
Relative change (95% CI)b | − 75.9 (− 81.9 to − 67.9) | − 68.2 (− 75.7 to − 58.4) | − 77.7 (− 83.4 to − 70.0) |
Patients with ≥ 50% reduction in Ki67 from baseline, % (95% CI) | 74.2 (55.4 to 88.1) | 68.6 (50.7 to 83.1) | 89.7 (72.6 to 97.8) |
Patients with post-treatment Ki67 ≤ 2.7%, % (95% CI)c | 16.1 (5.5 to 33.7) | 8.6 (1.8 to 23.1) | 13.8 (3.9 to 31.7) |
ER H-score | |||
Baselined | 286.6 (38.1) | 276.8 (37.9) | 289.5 (15.1) |
Day 15d | 103.7 (80.2) | 84.8 (67.0) | 248.8 (54.3) |
Absolute change (95% CI)e | − 176.7 (− 201.4 to − 152.0) | − 202.9 (− 226.1 to − 179.7) | − 32.5 (− 57.2 to − 7.7) |
Relative change (%)f | − 65.3 (− 100, 216) | − 68.3 (− 100, 3) | − 9.5 (− 81, 15) |
PgR H-score | |||
Baselined | 109.4 (90.1) | 121.6 (93.5) | 138.1 (102.2) |
Day 15d | 56.6 (70.7) | 55.1 (63.4) | 38.7 (51.1) |
Absolute change (95% CI)e | − 58.2 (− 78.4 to − 38.1) | − 68.3 (− 87.4 to − 49.2) | − 88.4 (− 110.1 to − 66.6) |
Relative change (%)f | − 70.0 (− 100, 5233) | − 74.4 (− 100, 3) | − 75.3 (− 100, 13) |