From: Trajectories of body mass index in adulthood and risk of subtypes of postmenopausal breast cancer
Ever MHT usea | Never MHT usea | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
ER + /PR + (n = 1956) | ER-/PR- (n = 342) | phetc | ER + /PR + (n = 2230) | ER-/PR- (n = 447) | phetc | |||||
Cases | MV-adjusted HR (95% CI)b | Cases | MV-adjusted HR (95% CI)b | Cases | MV-adjusted HR (95% CI)b | Cases | MV-adjusted HR (95% CI)b | |||
Age at onset (yrs)d | ||||||||||
BMI ≥ 25 | ||||||||||
Never OW | 1046 | Ref | 182 | Ref | 1151 | Ref | 261 | Ref | ||
< 40 | 283 | 0.95 (0.83–1.08) | 47 | 0.89 (0.64–1.23) | 469 | 1.22 (1.09–1.36) | 89 | 1.03 (0.80–1.31) | ||
40–49 | 392 | 1.13 (1.00–1.27) | 68 | 1.11 (0.84–1.47) | 455 | 1.37 (1.22–1.52) | 67 | 0.90 (0.69–1.19) | ||
≥ 50 | 235 | 1.04 (0.90–1.20) | 45 | 1.18 (0.85–1.64) | 155 | 1.10 (0.93–1.31) | 30 | 1.00 (0.68–1.48) | ||
ptrende | 0.21 | 0.26 | 0.85 | < 0.01 | 0.74 | 0.04 | ||||
BMI ≥ 30 | ||||||||||
Never OB | 1775 | Ref | 312 | Ref | 1946 | Ref | 403 | Ref | ||
< 40 | 22 | 0.73 (0.48–1.11) | 3 | 0.56 (0.18–1.74) | 56 | 1.00 (0.77–1.31) | 9 | 0.77 (0.40–1.50) | ||
40–49 | 66 | 0.92 (0.72–1.17) | 15 | 1.13 (0.67–1.91) | 115 | 1.26 (1.04–1.52) | 21 | 1.12 (0.72–1.75) | ||
≥ 50 | 93 | 1.02 (0.83–1.26) | 12 | 0.76 (0.43–1.36) | 113 | 1.56 (1.29–1.89) | 14 | 0.99 (0.58–1.70) | ||
ptrende | 0.81 | 0.45 | 0.64 | < 0.01 | 0.92 | 0.35 | ||||
Duration (per 10 yrs)d | ||||||||||
BMI ≥ 25 | 910 | 1.00 (0.96–1.04) | 160 | 0.98 (0.88–1.09) | 0.92 | 1,079 | 1.09 (1.05–1.13) | 186 | 0.98 (0.89–1.08) | 0.04 |
BMI ≥ 30 | 181 | 0.96 (0.85–1.08) | 30 | 0.91 (0.67–1.23) | 0.83 | 284 | 1.06 (0.97–1.17) | 44 | 0.97 (0.77–1.24) | 0.47 |
Intensity (per 100 units)d | ||||||||||
OWY | 910 | 0.95 (0.85–1.06) | 160 | 0.93 (0.71–1.22) | 0.99 | 1,079 | 1.10 (1.01–1.20) | 186 | 0.95 (0.76–1.19) | 0.21 |
OBY | 181 | 0.88 (0.62–1.24) | 30 | 1.05 (0.50–2.17) | 0.63 | 284 | 0.98 (0.76–1.26) | 44 | 0.89 (0.48–1.68) | 0.77 |
Trajectoriesf, g | ||||||||||
Normal-stable | 874 | Ref | 157 | Ref | 864 | Ref | 207 | Ref | ||
Normal-overweight | 822 | 1.04 (0.94–1.14) | 146 | 1.02 (0.81–1.28) | 0.92 | 943 | 1.14 (1.04–1.26) | 169 | 0.86 (0.70–1.05) | 0.01 |
Normal-obesity | 222 | 1.02 (0.88–1.18) | 33 | 0.82 (0.56–1.20) | 0.33 | 349 | 1.34 (1.18–1.52) | 57 | 0.91 (0.67–1.22) | 0.01 |
Overweight-obesity | 26 | 0.77 (0.52–1.14) | 5 | 0.79 (0.32–1.93) | 0.93 | 67 | 1.20 (0.93–1.54) | 11 | 0.81 (0.44–1.49) | 0.23 |
Obesity-decrease | 12 | 0.78 (0.44–1.37) | 1 | 0.39 (0.05–2.76) | 0.44 | 7 | 0.41 (0.20–0.87) | 3 | 0.79 (0.25–2.47) | 0.39 |
ptrende | 0.64 | 0.26 | <0.01 | 0.23 |