From: Trajectories of body mass index in adulthood and risk of subtypes of postmenopausal breast cancer
Luminal A-like (n = 3400) | Luminal B-like (n = 1324) | HER2-enriched (n = 235) | TNBC (n = 450) | phetb | |||||
---|---|---|---|---|---|---|---|---|---|
Cases | MV-adjusted HR (95% CI)a | Cases | MV-adjusted HR (95% CI)a | Cases | MV-adjusted HR (95% CI)a | Cases | MV-adjusted HR (95% CI)a | ||
BMI at wave 1c, d | |||||||||
Underweight | 72 | 1.14 (0.90–1.44) | 348 | 0.94 (0.63–1.40) | 1 | 0.20 (0.03–1.40) | 12 | 1.39 (0.78–2.48) | |
Normal weight | 2038 | Ref | 852 | Ref | 154 | Ref | 271 | Ref | |
Overweight | 966 | 1.11 (1.02–1.20) | 93 | 0.95 (0.84–1.08) | 62 | 0.99 (0.73–1.33) | 125 | 1.09 (0.88–1.35) | |
Obesity | 303 | 1.13 (1.00–1.28) | 6 | 0.81 (0.66–1.01) | 18 | 0.91 (0.55–1.50) | 41 | 1.14 (0.81–1.59) | |
ptrende | 0.01 | 0.09 | 0.82 | 0.54 | 0.06 | ||||
Age at onset (yrs)f | |||||||||
BMI ≥ 25 | |||||||||
Never OW | 1780 | Ref | 736 | Ref | 136 | Ref | 247 | Ref | |
< 40 | 609 | 1.10 (1.00–1.21) | 212 | 0.90 (0.77–1.05) | 39 | 0.90 (0.63–1.30) | 83 | 1.03 (0.80–1.33) | |
40–49 | 698 | 1.27 (1.16–1.39) | 230 | 1.00 (0.86–1.16) | 46 | 1.11 (0.79–1.56) | 74 | 0.95 (0.73–1.24) | |
≥ 50 | 313 | 1.04 (0.92–1.18) | 146 | 1.18 (0.99–1.42) | 14 | 0.68 (0.39–1.19) | 46 | 1.12 (0.81–1.55) | |
ptrende | < 0.01 | 0.14 | 0.41 | 0.66 | 0.03 | ||||
BMI ≥ 30 | |||||||||
Never OB | 3024 | Ref | 1199 | Ref | 216 | Ref | 403 | Ref | |
< 40 | 63 | 0.90 (0.70–1.16) | 18 | 0.63 (0.39–1.00) | 5 | 0.96 (0.39–2.34) | 7 | 0.70 (0.33–1.47) | |
40–49 | 145 | 1.10 (0.93–1.30) | 51 | 0.95 (0.72–1.26) | 11 | 1.11 (0.61–2.06) | 22 | 1.20 (0.78–1.86) | |
≥ 50 | 168 | 1.23 (1.05–1.44) | 56 | 1.03 (0.79–1.35) | 3 | 0.34 (0.11–1.05) | 18 | 0.98 (0.61–1.58) | |
ptrende | < 0.01 | 0.87 | 0.12 | 0.87 | 0.29 | ||||
Duration (per 10 yrs)f | |||||||||
BMI ≥ 25 | 1620 | 1.04 (1.00–1.07) | 588 | 0.93 (0.88–0.99) | 99 | 0.98 (0.86–1.12) | 203 | 0.98 (0.89–1.08) | 0.03 |
BMI ≥ 30 | 376 | 1.01 (0.93–1.10) | 125 | 0.88 (0.76–1.03) | 19 | 0.95 (0.67–1.34) | 47 | 0.96 (0.76–1.22) | 0.56 |
Intensity (per 100 units)f | |||||||||
OWY | 1620 | 1.03 (0.96–1.11) | 588 | 0.85 (0.74–0.97) | 99 | 0.96 (0.70–1.30) | 203 | 0.97 (0.78–1.20) | 0.16 |
OBY | 376 | 0.94 (0.75–1.18) | 125 | 0.61 (0.38–0.99) | 19 | 0.82 (0.31–2.15) | 47 | 1.08 (0.63–1.86) | 0.35 |
Trajectoriesg | |||||||||
Normal-stable | 1413 | Ref | 601 | Ref | 107 | Ref | 205 | Ref | |
Normal-overweight | 1432 | 1.09 (1.01–1.18) | 535 | 0.95 (0.84–1.06) | 96 | 0.96 (0.73–1.27) | 176 | 0.91 (0.74–1.11) | 0.16 |
Normal-obesity | 463 | 1.20 (1.08–1.33) | 159 | 0.94 (0.78–1.12) | 25 | 0.82 (0.53–1.28) | 57 | 0.96 (0.72–1.30) | 0.09 |
Overweight-obesity | 77 | 1.05 (0.84–1.33) | 21 | 0.64 (0.41–1.00) | 6 | 1.00 (0.44–2.30) | 9 | 0.78 (0.40–1.53) | 0.3 |
Obesity-decrease | 15 | 0.54 (0.33–0.90) | 8 | 0.67 (0.33–1.35) | 1 | 0.54 (0.08–3.88) | 3 | 0.76 (0.24–2.37) | 0.94 |
ptrende | 0.07 | 0.05 | 0.42 | 0.37 |