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Fig. 7 | Breast Cancer Research

Fig. 7

From: Integrative multi-omic sequencing reveals the MMTV-Myc mouse model mimics human breast cancer heterogeneity

Fig. 7

Mouse model genetic and transcriptional events inform human clinical outcomes. (A) Unsupervised hierarchical clustering of METABRIC gene expression values by a list of 453 homologous genes that are in a conserved amplification/deletion event and are differentially expressed between MMTV-Myc histological subtypes. (B) Unsupervised hierarchical clustering of METABRIC gene expression values by the PAM50 gene set. (C) Overall survival (OS) Kaplan–Meier (KM) analysis of non-redundant TCGA breast cancer patients, accessed through cBioPortal, stratified by Myc amplification status. (D) OS KM curve of non-redundant TCGA breast cancer patients stratified by KRAS alteration status. (E) OS KM curve of non-redundant TCGA breast cancer patients stratified by FGFR2 amplification status

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Breast Cancer Research

ISSN: 1465-542X

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