Fig. 6

Squamous represents an intermediate phenotype between microacinar and EMT. (A) PCA of the MSigDB C2 curated and (B) C6 oncogenic signature gene sets for ssGSEA values of the microacinar, squamous, and EMT tumors recapitulates C1 clustering and explains more variance in the data. (C) Pairwise relationship plots for representative C2 gene set and (D) C6 gene set ssGSEA values are shown with linear regression lines and a 95% CI. Pearson R correlation values are shown with p-values determined from a two-sided t-test