Skip to main content
Fig. 5 | Breast Cancer Research

Fig. 5

From: Integrative multi-omic sequencing reveals the MMTV-Myc mouse model mimics human breast cancer heterogeneity

Fig. 5

Heterogeneous activation of KRAS pathway in EMT histological subtype. (A) Proportion of each tumor histological subtype with activating mutations in KRAS in bar plot format. (B) Sequence variation in KRAS between all tumors sequenced as shown by a logo plot illustrates canonically activating mutations in KRAS. (C) A volcano plot of the ssGSEA values from the MSigDB C6 oncogenic signature gene set, showing EMT upregulated or downregulated gene sets compared to microacinar and squamous. (D) Violin plot of a representative KRAS pathway signature from the ssGSEA values of the C6 oncogenic signature gene set, showing distinct upregulation of KRAS signaling in the EMT subtype. (E) Heatmap of log2 fold change in copy number segmentation values showing high-level amplification of FGFR2 in EMT. (F) Canonical molecular pathway signaling reveals FGFR2 lies directly upstream of KRAS (Created with BioRender.com)

Back to article page

Breast Cancer Research

ISSN: 1465-542X

Contact us