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Fig. 4 | Breast Cancer Research

Fig. 4

From: Integrative multi-omic sequencing reveals the MMTV-Myc mouse model mimics human breast cancer heterogeneity

Fig. 4

Oncogenic drivers determine mutational heterogeneity. (A) Total counts of overall somatic mutational burden of MMTV-Myc tumors compared to mutational burden of MMTV-Neu and MMTV-PyMT tumors as shown by bar plot. (B) Weights of Catalogue of Somatic Mutations in Cancer (COSMIC) mutational signatures derived from each tumor using DeconstructSigs [48] depicted by stacked bar plot. (C) Venn diagram of conserved mutations (≥ 66% of tumors) between histological subtypes of moderate or high impact predicted by SnpEff. Putatively impactful oncogenes with Sanger sequencing confirmed mutations are listed by their representative histological subtype in which those mutations are conserved

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Breast Cancer Research

ISSN: 1465-542X

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