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Fig. 7 | Breast Cancer Research

Fig. 7

From: The loss of B7-H4 expression in breast cancer cells escaping from T cell cytotoxicity contributes to epithelial-to-mesenchymal transition

Fig. 7

The potential mechanism of breast cancer cells escaping from T cell cytotoxicity. We describe a novel mechanism associated with immune escape of tumor cells in the context of CAR-T cell therapy and tumor progression. Based on our findings, some B7-H4 positive tumor cells will loss B7-H4 molecule when tumor cells encounter CAR-T cells target B7-H4. The absence of B7-H4 expression in tumor cells promotes epithelial–mesenchymal transition (EMT) and cancer stem cell (CSC) differentiation, resulting in tumor migration, metastasis and chemoresistance. Our study provided new insights into the role of EMT and CSC in tumor immune escape

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Breast Cancer Research

ISSN: 1465-542X

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