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Fig. 6 | Breast Cancer Research

Fig. 6

From: The loss of B7-H4 expression in breast cancer cells escaping from T cell cytotoxicity contributes to epithelial-to-mesenchymal transition

Fig. 6

The fluctuation of B7-H4 expression levels among breast tumor stages might be associated with the immune escape of breast cancer cells in certain stages. A The expression levels of B7-H4 in terms of stages of breast cancer were evaluated according to the TCGA database (n = 932). B The selected 45 breast cancer patients were identified from the TCGA database with parallel expression patterns in which B7-H4 legitimizes EMT- and cell stemness-related genes. C The selected 45 patients were divided into high and low groups according to the population’s median value of B7-H4 expression. The patient number between the two groups was calculated in each stage. D B7-H4 protein expression levels in breast cancer tissues were detected by immunohistochemical staining (Scale bar = 50 μm), and the odd ratios of tumor stages between high versus low B7-H4 groups were computed using the chi-squared test. (n = 41)

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Breast Cancer Research

ISSN: 1465-542X

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