Table 1 Patient and tumor characteristics
Characteristics | Patients with gene signatures (n = 437) | Patients without gene signatures (n = 123) | ||
|---|---|---|---|---|
Control group n (%) | Tam-treated group n (%) | Control group n (%) | Tam-treated group n (%) | |
Age (years) | ||||
 Median | 45 | 45 | 45 | 47 |
 Range | 27–54 | 26–57 | 29–58 | 31–55 |
Tumor size (mm) | ||||
 ≤ 20 | 86 (39) | 69 (32) | 35 (55) | 17 (29) |
 > 20 | 134 (61) | 148 (68) | 29 (45) | 41 (71) |
 Missing | 0 | 0 | 0 | 1 |
Nodal status | ||||
 Node-negative | 57 (26) | 62 (29) | 18 (28) | 21 (36) |
 Node-positive | 162 (74) | 154 (71) | 46 (72) | 38 (64) |
 N1 | 105 (48) | 108 (50) | 34 (53) | 28 (48) |
 N2 | 57 (26) | 46 (21) | 12 (19) | 10 (17) |
 Missing | 1 | 1 | 0 | 0 |
NHG | ||||
 1 | 24 (11) | 22 (11) | 1 (15) | 5 (11) |
 2 | 88 (42) | 87 (43) | 27 (52) | 18 (38) |
 3 | 99 (47) | 93 (46) | 17 (33) | 24 (51) |
 Missing | 9 | 15 | 12 | 12 |
ER | ||||
 Positive | 154 (70) | 139 (66) | 37 (64) | 32 (63) |
 Negative | 63 (29) | 72 (34) | 21 (36) | 19 (37) |
 Missing | 3 | 6 | 6 | 8 |
PR | ||||
 Positive | 148 (68) | 132 (61) | 37 (64) | 31 (62) |
 Negative | 71 (32) | 84 (39) | 21 (36) | 19 (38) |
 Missing | 1 | 1 | 6 | 9 |
HER2 | ||||
 Negative | 166 (82) | 167 (87) | 37 (95) | 30 (88) |
 Positive | 36 (18) | 26 (12) | 2 (5) | 4 (12) |
 Missing | 18 | 24 | 25 | 25 |
Ki67 (%) | ||||
 Median | 34 | 32 | 27 | 28 |
 Range | 2–89 | 3–88 | 7–53 | 9–51 |
 Missing | 16 | 14 | 41 | 43 |
Histopathological type | ||||
 Ductal/NST | 177 (86) | 167 (82) | 32 (74) | 33 (85) |
 Lobular | 16 (8) | 18 (9) | 6 (14) | 3 (8) |
 Medullary | 10 (5) | 10 (5) | 4 (9) | 1 (3) |
 Other | 4 (2) | 8 (4) | 1 (2) | 2 (5) |
 Missing | 13 | 14 | 21 | 20 |
TILs (%) | ||||
 < 10 | 111 (51) | 116 (54) | 18 (58) | 7 (35) |
 10–49 | 79 (36) | 67 (31) | 7 (23) | 8 (40) |
 50–100 | 28 (13) | 34 (16) | 6 (19) | 5 (25) |
Missing | 2 | 0 | 33 | 39 |
PAM50 subtype | ||||
 Luminal A | 101 (46) | 90 (42) | – | – |
 Luminal B | 41 (19) | 42 (19) | – | – |
 HER2-enriched | 39 (18) | 35 (16) | – | – |
 Basal-like | 39 (18) | 50 (23) | – | – |
 Missing | 0 | 0 | 59 | 59 |