Fig. 8

a–d Forest plot of GEX signatures and association to outcomes. Outcomes of GEX signatures as continuous variables in all patients for a RFi at 10 years of follow-up, b RFi at full follow-up, c OS at 10 years, and d OS at full follow-up. All plots a–d represent data from the entire cohort for which GEX data were available (n = 437). Plots represent data from univariable Cox regression, with HR plotted with 95% CI, and the color corresponds to the significance level. Data from univariable Cox regressions are presented as HR with the corresponding q (FDR-adjusted p-value). *Data from multivariable Cox regressions adjusted for PAM50 subtype, node category, age, NHG, tumor size, and tamoxifen arm, calculated only for signatures where the univariable Cox regression p was < 0.05. adj adjusted, CI confidence interval, ER estrogen receptor, FDR false discovery rate, FU follow-up, GEX gene expression, HR hazard ratio, HER2 human epidermal growth factor receptor 2, n number of patients, NHG Nottingham histological grade, OS overall survival, RFi recurrence-free interval