Fig. 5

a, b Tamoxifen effect in relation to GEX signatures and OS. Forest plots illustrating the effect of tamoxifen on OS in patients with ER+/HER2− tumors. Plots represent results from univariable Cox regression analyses, with HR plotted with 95% CI, and the color corresponds to the significance level. The results from univariable Cox regression analysis are presented as HR with corresponding q (FDR-adjusted p value). * Results from multivariable Cox regressions adjusted for PAM50 subtype, node category, age, NHG, and tumor size, calculated only for signatures where the univariable Cox regression p was < 0.05. adj. adjusted, CI confidence interval, ER estrogen receptor, FDR false discovery rate, FU follow-up, GEX gene expression, HER2 human epidermal growth factor receptor 2, n number of patients, NHG Nottingham histological grade, OS overall survival