Fig. 4

a, b Tamoxifen effect in relation to GEX signatures and RFi. Forest plots illustrating the effect of tamoxifen on RFi in patients with ER+/HER2− tumors. Plots represent results from univariable Cox regression, with HR plotted with 95% CI, and the color corresponds to the significance level. The results from the univariable Cox regression analysis are presented as HR and the corresponding q (FDR-adjusted p-value). * Results from multivariable Cox regression analyses adjusted for PAM50 subtype, node category, age, NHG, and tumor size calculated only for signatures where the univariable Cox regression p was < 0.05. adj. adjusted, CI confidence interval, ER estrogen receptor, FDR false discovery rate, FU follow-up, GEX gene expression, HER2 human epidermal growth factor receptor 2, n number of patients, NHG Nottingham histological grade, RFi recurrence-free interval