Fig. 3

Heatmap illustrating expression levels of the GEX signatures. Heatmap of GEX signatures for all patients (n = 437); tumors in rows, and GEX signatures in columns. Expression levels are presented as z-scores from low (green) to high (red) expression. The panels on the right show the intrinsic subtype, tumor size, node status, and TILs score for each tumor. 1–4 illustrate the four GEX signature clusters generated using k-means clustering. The bottom panels present the relationships between PAM50 subtypes and GEX signatures, both as continuous variables and color-coded according to Pearson correlation coefficients. GEX gene expression, HER2-E human epidermal growth factor receptor 2-enriched, Lum luminal, TILs tumor-infiltrating lymphocytes, T1 tumor size ≤ 20 mm, T2 tumor size > 20 mm