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Table 2 Association of ESR1 and PIK3CA codon variants and alterations in oncogenic pathways with overall survival (OS).

From: Interplay between ESR1/PIK3CA codon variants, oncogenic pathway alterations and clinical phenotype in patients with metastatic breast cancer (MBC): comprehensive circulating tumor DNA (ctDNA) analysis

 

HR

95% C.I

P value

ESR1 variants

 Wild type

1

   

 537

1.08

0.68

1.71

0.7594

 538

0.77

0.46

1.32

0.3446

 380

2.48

1.01

6.07

0.0476

 536

1.06

0.41

2.74

0.9071

PIK3CA variants

 Wild type

1

   

 1047

0.97

0.6

1.55

0.8871

 545

0.61

0.34

1.08

0.089

 542

1.12

0.65

1.91

0.6849

RAS pathway SNVs

 Not altered

1

   

 Altered

1.96

1.16

3.33

0.0126

P53 pathway SNVs

 Not altered

1

   

 Altered

1.38

1.02

1.86

0.0341

Cell cycle pathway SNVs

 Not altered

1

   

 Altered

1.07

0.53

2.16

0.8576

ER pathway SNVs

 Not altered

1

   

 Altered

1.41

0.84

2.36

0.1948

PI3K pathway SNVs

 Not altered

1

   

 Altered

1.57

0.93

2.66

0.0925

RTK pathway CNVs

 Not altered

1

   

 Altered

1.2

0.77

1.86

0.4269

RAS pathway CNVs

 Not altered

1

   

 Altered

0.84

0.34

2.08

0.7009

RAF pathway CNVs

 Not altered

1

   

 Altered

0.91

0.32

2.55

0.8563

ER pathway CNVs

 Not altered

1

   

 Altered

0.93

0.23

3.83

0.9222

MYC pathway CNVs

 Not altered

1

   

 Altered

1.91

1.08

3.38

0.027

Cell cycle pathway CNVs

 Not altered

1

   

 Altered

1.27

0.79

2.05

0.3275

PI3K pathway CNVs

 Not altered

1

   

 Altered

2.27

1.16

4.47

0.0174

Lung involvement

 No

1

   

 Yes

1.28

0.96

1.73

0.0961

Liver involvement

 No

1

   

 Yes

1.84

1.36

2.5

0.0001

Bone involvement

 No

1

   

 Yes

1.66

1.13

2.43

0.0093

Soft tissue involvement

 No

1

   

 Yes

2.01

1.41

2.85

0.0001

Previous CDK4/6i

 No

1

   

 Yes

1.14

0.82

1.58

0.4464

Treatment line

 First

1

   

 Second

2.24

1.39

3.63

0.001

 Third

3.58

2.16

5.94

 < 0.0001

 Fourth

2.44

1.34

4.43

0.0035

 Fifth and beyond

3.52

2.18

5.68

 < 0.0001

  1. CNVs, Copy Number Variations; SNVs, Single Nucleotide Variations
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Breast Cancer Research

ISSN: 1465-542X

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