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Fig. 2 | Breast Cancer Research

Fig. 2

From: Interplay between ESR1/PIK3CA codon variants, oncogenic pathway alterations and clinical phenotype in patients with metastatic breast cancer (MBC): comprehensive circulating tumor DNA (ctDNA) analysis

Fig. 2

Heat-map showing the association of the main ESR1 and PIK3CA codon variants with concomitant ctDNA alterations in other oncogenic pathways. PIK3CA 1047 was associated with SNVs in the P53 pathway and CNVs in the PI3K, while PIK3CA 542 with CNVs in the PI3K pathway, SNVs in the RTK and SNVs in the RAS and PIK3CA 545 with SNVs in the P53 pathway. ESR1 537 was associated with SNVs in the ER pathway, CNVs in the MYC and SNVs in the RAF, ESR1 538 with SNVs in cell cycle pathway. Color intensity was proportional to Odds Ratio, while P value was described by size (the lower the P value, the bigger the circle). Syn, Synonymous; Ukn, Unknown; CNVs, Copy Number Variations; SNVs, Single Nucleotide Variations

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Breast Cancer Research

ISSN: 1465-542X

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