Fig. 2

Association dot plot all data technologies with OS and rCR. In this dot plot all significant associations in at least one analysis are shown. Blue dots indicate increased overall survival or higher likelihood of radiological complete response. Red dots indicate decreased overall survival or lower likelihood of radiological complete response. The size of the dot is proportional to the P value with larger dots indicating a smaller P value. The background color is white for P < 0.05, light gray for P > 0.05 and < 0.10 and gray for P ≥ 0.10. P values shown are not adjusted for multiple testing. Data from both primary tumors and metastases are analyzed, indicated on the left and by red and pink boxes, respectively. Analyses in subgroups are indicated by colors: hormone-receptor subgroup analyses (orange) and radiological complete response subgroup (blue). Analyses adjusted for radiological complete response are indicated by blue boxes as well. Dark green boxes indicate associations with overall survival. Light green boxes indicate association with radiological complete response. Overarching pathways are indicated by colors on top. Platform can be gene expression (yellow), TMA IHC (orange), or TMA MIF (red). Type refers to whether TMA measurements are of an individual cell type (lavender), proliferating cells (purple), or cell–cell spatial relationships (dark purple)