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Fig. 6 | Breast Cancer Research

Fig. 6

From: The BET degrader ZBC260 suppresses stemness and tumorigenesis and promotes differentiation in triple-negative breast cancer by disrupting inflammatory signaling

Fig. 6

ZBC260 decreases the expression of inflammatory genes. (a–h) Effect of ZBC260 or vehicle treatment on gene expression in ALDH− and ALDH+ cell populations of SUM159 cells. The expression of genes was normalized to GAPDH. i Heatmap showing relative RNA expression of genes after ZBC260 treatment. j Effect of ZBC260 or vehicle treatment on the secretion of inflammatory cytokines in ALDH− and ALDH+ cell populations of SUM159 cells. Secretion of cytokine was measured in the conditioned media by ELISA assay and fold change was calculated relative to control. Data points are the mean ± SEM for individual experiments, n = 3 independent experiments. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001. The results presented are representative graphs of at least 3 biological replicates

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Breast Cancer Research

ISSN: 1465-542X

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