Table 2 Predictive factors (Cox regression analysis)
From: Receptor conversion and survival in breast cancer liver metastases
Univariate analysis | Multivariable analysis | |
|---|---|---|
Predictive factor | HR (95% CI); p value | HR (95% CI); p value |
Age at BC | 1.018 (1.002–1.033); 0.028 | 0.867 (0.728–1.032); 0.109 |
Age at BCLM | 1.017 (1.001–1.034); 0.036 | 1.167 (0.980–1.390); 0.083 |
Time BC to BCLM | 0.998 (0.990–1.007); 0.729 | |
TNM BC | ||
1 | Ref = 1.000; 0.438 | |
2 | 0.739 (0.499–1.217); 0.235 | |
3 | 0.911 (0.455–1.825); 0.739 | |
NHG BC | ||
1 | 0.629 (0.228–1.738); 0.371 | 0.409 (0.112–1.485); 0.174 |
2 | 0.490 (0.315–0.764); 0.002 | 0.504 (0.275–0.924); 0.027 |
3 | Ref = 1.000; 0.007 | Ref = 1.000; 0.083 |
No of BCLM | ||
> 1 | Ref = 1.000 | Ref = 1.000 |
Single | 0.538 (0.322–0.896); 0.017 | 0.545 (0.283–1.048); 0.069 |
Extrahepatic met | ||
Yes | Ref = 1.000 | |
No | 1.007 (0.679–1.495); 0.971 | |
Conversion | ||
Yes | Ref = 1.000 | |
No | 0.906 (0.552–1.485); 0.695 | |
Vascular invasion BC | ||
No | Ref = 1.000 | |
Yes | 1.020 (0.641–1.623); 0.935 | |
ER BC | ||
Negative | Ref = 1.000 | Ref = 1.000 |
Positive | 0.651 (0.427–0.994); 0.047 | 0.711 (0.365–1.383); 0.315 |
PgR BC | ||
Negative | Ref = 1.000 | Ref = 1.00 |
Positive | 0.588 (0.392–0.883); 0.010 | 0.443 (0.223–0.879); 0.020 |
HER2 BC | ||
Negative | Ref = 1.000 | Ref = 1.000 |
Positive | 0.471 (0.241–0.921); 0.028 | 0.277 (0.085–0.901); 0.033 |
ER BCLM | ||
Negative | Ref = 1.000 | |
Positive | 0.766 (0.505–1.162); 0.210 | |
PgR BCLM | ||
Negative | Ref = 1.000 | Ref = 1.000 |
Positive | 0.468 (0.267–0.823); 0.008 | 0.757 (0.341–1.682); 0.495 |
HER2 BCLM | ||
Negative | Ref = 1.000 | Ref = 1.000 |
Positive | 0.604 (0.345–1.059); 0.078 | 0.731 (0.292–1.828); 0.503 |