Table 1 Features of canine mammary tumor subtypes and subgroups
From: Human basal-like breast cancer is represented by one of the two mammary tumor subtypes in dogs
Subtype | cBLMT1 | cNBLMT2 | |||
|---|---|---|---|---|---|
Subgroup | ER−PR− | ER−PR+  | ER+PR+ | ER+PR− | 96% ER+PR+ |
Basal-like | 17 | 18 | 6 | 3 | 5 |
Luminal A | 0 | 0 | 4 | 2 | 55 |
Luminal B | 2 | 1 | 6 | 1 | 8 |
HER2-enriched | 1 | 3 | 2 | 0 | 2 |
Normal-like | 0 | 1 | 2 | 0 | 4 |
Enriched functions of upregulated genes in subgroup | Hedgehog signaling; EMT; Wnt/β-catenin signaling | Interferon-γ response; IL6/JAK/STAT3 Signaling; Wnt & pluripotency | Interferon-γ response; Hedgehog signaling | ND3 |  |
Histological & clinical features | Simple adenoma/carcinoma enriched; tumor with lymph node invasion enriched | Complex or mixed tumors enriched | |||
Enriched functions of upregulated genes in subtype | Cell cycle; proliferation; MYC target; Wnt signaling; EMT; basal-like upregulation | Ion transport; ESR1 targets; basal-like downregulation | |||
Mutation enrichment | TP53 mutation | PIK3CA H1047R/L; KAT6B mutation; PI3K-AKT-mTOR pathway alteration | |||
Cross-species PAM50 | Clustered with hBLBC | Not clustered with any human breast cancer subtype | |||