Fig. 5
From: Human basal-like breast cancer is represented by one of the two mammary tumor subtypes in dogs
Basal-like features are maintained in all cBLMT subgroups, especially in ER−PR+ and ER−PR− cBLMTs. A–C. Heatmaps showing the DE genes identified between cNBLMT and each of the ER−PR− A, ER−PR+ B, and ER + PR + C cBLMT subgroups, with a BH-adjusted p-value of < 0.05 and an expression-fold change of > 2. The heatmaps are presented as described in Fig. 3A, along with TMB and the most mutated genes indicated as described in Fig. 1. A tumor was classified ER+ or PR+ if its ESR1 or PGR gene has a FPKM value of > 1, respectively; otherwise, the tumor was classified ER− or PR−. D–F. Heatmaps of DE genes identified between ER ± PR ± cBLMT subgroups, presented as described in A–C