Fig. 3
From: Human basal-like breast cancer is represented by one of the two mammary tumor subtypes in dogs
Differentially expressed (DE) gene analysis indicates the enrichment of hBLBC signatures in cBLMT. A. Heatmap of the row scaled log2(TPM) values of 1,620 DE genes between cBLMT and cNBLMT samples, identified with an expression fold change of > 2 and a BH-adjusted p-value of < 0.01 for each DE gene (see Methods). The enriched functions among each DE gene group are indicated. B & C Distribution of single sample gene set enrichment analysis (ssGSEA) scores of canine tumors with hBLBC signature gene sets B, as well as with gene sets with expression patterns characterizing each human breast cancer subtype [51] shown C. P-values are from Wilcoxon tests. *: p < 0.05; ****: p < 0.0001