Evaluation of the association of area-level socioeconomic deprivation and breast cancer recurrence by oestrogen receptor subtypes in Scotland

Table 3 Fully adjusted Cox proportional hazards model for breast cancer recurrence (IBR) among ER-negative patients censored at 5 years stratified by surgery type

Exposure^d	ER-negative patients^c (n = 676) 155 IBR events	ER-negative patients with breast conservation^c (n = 332) 55 IBR events	ER-negative patients with mastectomy^c (n = 339) 100 IBR events
	HR (95% CI)
Age < 50	(reference)	(reference)	(reference)
Age 50–70	0.82 (0.56–1.22)	0.95 (0.49–1.85)	0.70 (0.43–1.15)
Age 70 +	1.33 (0.78–2.26)	0.74 (0.23–2.40)	1.31 (0.72–2.38)
SIMD 1^a	(reference)	(reference)	(reference)
SIMD 2	1.45 (0.91–2.31)	0.87 (0.39–1.95)	1.93 (1.07–3.47)
SIMD 3	1.88 (1.19–2.96)	1.24 (0.57–2.67)	2.15 (1.20–3.47)
SIMD 4	0.93 (0.53–1.65)	0.87 (0.35–2.20)	1.00 (0.48–2.10)
SIMD 5	2.10 (1.18–3.73)	1.24 (0.57–2.67)	3.03 (1.41–6.53)
TNM stage 1	(reference)	(reference)	(reference)
TNM stage 2/3	1.47 (0.86–2.50)	1.33 (0.66–2.66)	2.06 (0.71–5.96)
Grade 1/2^b	(reference)	(reference)	(reference)
Grade 3	1.25 (0.77–2.03)	2.05 (0.78–5.41)	1.28 (0.72–2.28)
Not screen detected	(reference)	(reference)	(reference)
Screen detected	0.63 (0.36–1.09)	0.98 (0.46–2.08)	0.30 (0.10–0.84)
Breast-conserving surgery	(reference)	–	–
Mastectomy	2.66 (1.75–3.77)	–	–
Chemotherapy	1.24 (0.73–2.10)	0.94 (0.38–2.33)	1.49 (0.76–2.90)
Radiotherapy	1.96 (1.28–3.00)	0.17 (0.07–0.41)	2.59 (1.57–4.02)

^aSIMD 1 represents the most affluent area. SIMD 5 represents the most deprived area
^bGrades 1 and 2 were collapsed in the ER-model as there were very few cases in either category
^cAnalyses censored at 5 years
^dCancer network was included in these multivariable models

ISSN: 1465-542X