Circulating 27-hydroxycholesterol, lipids, and steroid hormones in breast cancer risk: a nested case–control study of the Multiethnic Cohort Study

Table 1 Circulating levels of biomarkers of interest according to case–control status among postmenopausal females, the Multiethnic Cohort

Biomarkers of interest	Matched pairs	Controls				Breast cancer cases
Biomarkers of interest	N	Mean	SD	Min	Max	Mean	SD	Min	Max
27HC (ng/mL)	1470	83.89	22.45	33.08	261.9	82.63	21.58	0.57	200.46
Lipids^a
HDL-C (mg/dL)	1466	51.96	19.04	1.00	146	44.49	17.17	2.64	131.05
LDL-C (mg/dL)	1455	131.96	39.25	25.20	346.4	135.31	37.95	25.00	307.20
Triglycerides (mg/dL)	1466	120.46	73.27	20.00	1000	118.84	79.41	21.00	995.00
Total cholesterol (mg/dL)	1466	207.69	41.68	49.70	500	203.58	38.79	77.00	438.14
Steroid hormones^b
Estrone (pg/mL)	1469	563.16	1472.85	2.50	27,713	633.25	1477.97	2.50	19,708.89
Testosterone (pg/mL)	1469	129.78	171.65	5.00	5300.3	150.19	240.96	5.00	8056.94
SHBG (nM)	1470	77.13	53.51	6.36	404	68.23	51.01	6.00	404.00

^aLipid assays were conducted as part of a previous study, so not all cases had lipid assay measurements available (4 of 1470 matched pairs missing). An additional 11 matched pairs are missing for LDL-C, because LDL-C levels are derived from fasting triglyceride levels and samples with fasting triglyceride levels over 400 mg/dl were excluded from this derivation procedure
^bOne sample missing from steroid hormone assays
27HC 27-hydroxy cholesterol, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol (calculated), SHBG sex hormone binding globulin, SD standard deviation

ISSN: 1465-542X